|
There are 89 known sequences today in the microRNA 19 (miR-19) family but it will change quickly. They are found in a large number of vertebrate species. The miR-19 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. Within the human and mouse genome there are three copies of this microRNA that are processed from multiple predicted precursor hairpins: * mouse: : * miR-19a on chromosome 14 ((MI0000688 )) : * miR-19b-1 on chromosome 14 ((MI0000718 )) : * miR-19b-2 on chromosome X ((MI0000546 )) * human:〔 : * miR-19a on chromosome 13 ((MI0000073 )) : * miR-19b-1 on chromosome 13 ((MI0000074 )) : * miR-19b-2 on chromosome X ((MI000075 )). MiR-19 has now been predicted or experimentally confirmed ((MIPF0000011 )). In this case the mature sequence is excised from the 3' arm of the hairpin precursor. == Origins == MicroRNA are ubiquitous in higher eukaryotes, and show varying patterns of expression in specific cell types. MiR-19 has been identified in a diverse range of vertebrate animals including green anole (''Anolis carolinensis''), primates (gorilla, human, ...), cattle (''Bos taurus''), dog (''Canis familiaris''), Chinese hamster (''Cricetulus griseus''), zebrafish (''Danio rerio''), horse (''Equus caballus''), ''Takifugu rubripes'',〔''Tetraodon nigroviridis'',〔 chicken (''Gallus gallus''), gray short-tailed opossum (''Monodelphis domestica''), platypus (''Ornithorhynchus anatinus''), Japanese medaka (''Oryzias latipes''), ''Xenopus laevis'' (frog), Tasmanian devil (''Sarcophilus harrisii''), pig (''Sus scrofa'') and zebra finch (''Taeniopygia guttata''). In some of these species the presence of miR-19 microRNAs have been directly measured, in other species genes have been identified with sequences that are predicted to encode miR-19.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Mir-19 microRNA precursor family」の詳細全文を読む スポンサード リンク
|